Agha Hussaini was associated to legendary film producer and director Anwar Kemal Pasha, and assisted him in films like 2 Aansoo (1950), Ghulam (1953), Gumnam (1954) and Sarfarosh (1956).
His first film as independent film director was Zulfan in 1957. His other famous films were 16 Aanay (1959), Khyber Mail (1960), Baghi Sipahi (1964), Koh-e-Noor (1966), Sipah Salar (1972) and Qismat Wala (1988).
Agha Hussaini died in 1994.