Safdar Hussain was recommended by his instructor and relative (Mamu) great musician Rasheed Attray to the director Nazir. Film Heer was super hit and Safdar Hussain became favorite music director for Karachi based film company Eveready Pictures who latter made a film Ishq-e-Laila in the competition with Lahore based film company Evernew Picture's Laila Majnu. Ironically, Safdar Hussain's "rival" in this competition was his own instructor and uncle Rasheed Attray - the battle was won by Safdar Hussain who composed not less than 19 songs in the film and most of them were all time super hit songs. It was Pakistan's biggest musical film with largest numbers of songs and most super hit songs as well.
Safdar Hussain's some other famous movies were Hameeda (1956), Nooran (1957), Nagin and Naji (1959), Dil kay Tukray (1965), Naghma-e-Sehra (1966), Shab Bakhair (1967), Janab-e-Aali (1968), Thah (1972), Pehla War (1973), Khatarnaak (1974), Wehshi Jatt (1975), Wardat (1976), Ghunda (1978), Wadda Khan (1983), Meri Awaz (1987).
His son Abbas Safdar also composed songs in a film Ruqqa in 1993 but could not succeed.
Safdar Hussain died on March 24, 1989.