He was introduced in film Jamalo (1962) and got break through from film Zamindar (1966). He was third most popular Punjabi film comedian actor after Rangeela and Munawar Zarif. Some of his famous movies were Roti (1968), Mukhra Chann Warga and Dia aur Toofan (1969), Jind Jan (1970), Mastana Mahi (1971), Doulat aur Dunya (1972) etc.
Khalifa Nazir was producer of many big movies like Akbara (1967), Anwara (1970), Doulat aur Dunya (1972), Ghulam (1973) etc. He was first hero with Asiya in film Mastana (1973).
Khalifa Nazir died on April 26, 2005 at Lahore.